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DAN 004
CAS No.
DAN 004 ( DAN004; DAN-004 )
Catalog No. M17098 CAS No.
A small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameDAN 004
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM.
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DescriptionA small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM; potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.
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SynonymsDAN004; DAN-004
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight494.43
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Molecular FormulaC26H28BrN3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N[C@H](C(N(CCCN)CC1=CC=C(Br)C=C1)=O)CC2=CC=CC=C2)C3=CC=CC=C3
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Chemical Name(S)-N-(1-((3-aminopropyl)(4-bromobenzyl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Aromadendrin
Aromadendrin is a natural product.?It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression,?possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activityAromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties.?
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BI-3802
BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.
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Bcl-xL antagonist 2
Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin’s lymphoma.
